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Study Examines Genitourinary Cancer Trends, Disparities in the

“These data are a call to arms. Prostate cancer can be readily treated and eradicated when detected in early stage, yet this cancer type persists as the second leading cause of cancer death amongst [male patients] in the United States. Moreover, overall trends show a deeply concerning shift toward diagnosis of later stage disease. We can and must do more.

underscored senior study author Karen E. Knudsen, MBA, PhD, Chief Executive Officer of the American Cancer Society (ACS) and the ACS Cancer Action Network, highlighting that “This study reveals striking geographic and racial disparities that should be studied and mitigated. Our data identify a significant burden on a subset of populations, including [male patients] in the West and Black [male patients] overall. [The] ACS is committed to being part of the change, toward advancing prevention programs, early detection of disease, and better medical treatment and care for [patients with] prostate cancer.”

Study Methods and Findings
For this study, the investigators analyzed incidence rates for bladder, kidney, prostate, and testicular cancers in the United States from the Surveillance, Epidemiology, and End Results (SEER) Database at the National Cancer Institute; mortality rates from the U.S. Cancer Statistics database from the Center for Disease Control and Prevention (CDC); and data from the National Center for Health Statistics. The investigators examined cross-sectional and temporal trends in incidence and mortality rates—stratified by sex, race and ethnicity, and county—calculated age-adjusted incidence and mortality rates by the National Cancer Institute’s SEER Stat software, and analyzed temporal trends using the Joinpoint Regression Program.

The study results showed that incidence rates increased for kidney and testicular cancers and for advanced-stage prostate cancer in almost all racial and ethnic populations. Additionally, the investigators also reported that incidence and mortality rates for bladder and kidney cancers continued to be two to four times higher in male patients than in female patients.
Other key findings from the study included.

Conclusions
“Previous studies have reported that differences in prevalence of cigarette smoking, obesity, and consumption of unhealthy [foods]—as well as inequity in receipt of standard of care—may have contributed to the disparities in incidence and mortality rates for some of the genitourinary cancers,” explained lead study author Elizabeth Schafer, MPH, an associate scientist II in Surveillance and Health Equity Science at the ACS. “However, further [investigation] is needed to better understand the causes of these disparities and help save lives.”

“The continued increase in both the incidence, and the percentage of [male individuals] presenting with regional- and advanced-disease prostate cancer is quite concerning,” stressed contributing study author William Dahut, MD, Chief Scientific Officer of the ACS, concluding that “Some of this can be explained by changes in screening patterns but the persistence of this finding suggests the possibility of a biologic or environmental factor.”

The investigators noted that further research may be needed to elucidate the reasons behind these patterns, to plan interventions preventing a greater rise in the burden of genitourinary cancers, and to mitigate the sociodemographic disparities recognized by the study.

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Police arrest husband of missing Massachusetts woman

BOSTON (AP) — The husband of a missing Massachusetts woman was arrested Sunday for allegedly misleading investigators, according to the office of Norfolk District Attorney Michael Morrissey.

Massachusetts State Police and local police took Brian Walshe, 46, of Cohasset, Massachusetts into custody after concluding they had “probable cause” to believe he had misled investigators into the search for his 39-year-old wife, Ana Walshe. She has been missing since New Year’s Day.

The announcement of Brian Walshe’s arrest came after Massachusetts State Police and local police said in a joint statement that their ground search for Ana Walshe or evidence related to her disappearance concluded Saturday.

A specialized State Police unit trained in search and rescue operations, three K-9 teams and the State Police Air Wing searched wooded areas near Walshe’s home Saturday. State Police divers searched a small stream and a pool but did not find anything, the statement said. The Metropolitan Law Enforcement Council also helped with the search.

Walshe, the mother of three young children, was last seen a week ago in her Cohasset home, police said.

She was reported missing Wednesday by her husband in Cohasset and her employer in Washington, according to The Patriot Ledger. The couple owns a home in Washington and Walshe commutes during the week for work at a real estate company, her friends said.

While police searched for Walshe on Friday, there was a fire at a home in Cohasset she owned until last year. The home was sold in March. State Police and local investigators determined the cause of the fire was accidental. The current occupants escaped safely.

The investigation into Walshe’s disappearance is ongoing. Authorities returned to her home Sunday, while detectives from Cohasset and the State Police were also in Washington investigating, according to The Boston Globe.

Brian Walshe, is awaiting sentencing in a fraud case involving the sale of fake Andy Warhol paintings, according to court records. Cohasset police said Walshe’s disappearance and her husband’s case seem to be two very separate things, The Boston Globe reported.

He is scheduled to be arraigned Monday on the latest charges in Quincy District Court. It was unclear if Brian Walshe has an attorney and a phone number for him could not be found.
Copyright 2023 Associated Press. All rights reserved.

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The top 10 real estate markets seeing the biggest changes. Some

As the U.S. housing market cools down, bidding wars are now a distant memory and many homebuyers and sellers are waiting to see how prices shake out before making a move.

Nationwide, the number of days homes stayed on the market rose by 67% to 35 days in October, up from 21 days last October, showing that higher mortgage rates —which have doubled since last year — have combined with inflation and pessimism about the economy to weigh on the real estate market.

But housing market conditions at the local level varied greatly, according to a report by House Method.

“A lot of the metros where there was a huge decrease in the days on market were a lot of very small, less expensive towns and metros,” says Caroline Jones, who analyzed data for Housing Method. “It shows that many people are not really able to afford a house in the more popular, more expensive metros anymore.”

This list of locations where homes spent fewer days on the market was dominated by Pennsylvania metros, four of which, including Harrisburg and Lancaster, stayed on the market for just over a week on average. The median sale price in that state rose 9.5% from $192,000 in October 2021 to $210,000 in 2022, well below the U.S. median home price of $379,100.

Housing market predictions:Six experts weigh in on the real estate outlook in 2023
Top 10 real estate markets for 2023:Goodbye COVID boomtowns, hello mid-sized markets
Housing market:What’s happening with the housing market? Mortgage rates, home prices and affordability.

By contrast, homes in Midwestern markets appear to be selling fast, with Indiana, Kansas, Michigan, and Nebraska among the top 10.

Some of the markets that saw the biggest percentage increase in the amount of time homes took to sell were places that also saw big price increases during the pandemic.

For instance, in North Port, Florida, the number of days homes took to sell rose by 263% this October compared with the same time last year. Just before the pandemic, in February 2020, the median price of a home sold in North Port stood at $230,000. In July 2022, it had shot up to $410,000.

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Top 10 Trusted IT Companies in USA 2023

The companies are shortlisted based on many parameters like client reviews, work experience, development skills, average hourly rate, project size, company strength and many more.

Growth, demand, ROI, and achieving goals are the things that every business desires to achieve quickly. One of the more reliable ways to achieve them is by stepping into the digital world with the help of IT companies. IT companies offer various services and solutions to businesses that can help them to enhance their working ability and services making it accurate to match the international level.

As each stage of the business demands expertise in different technologies, reaching out to top IT companies seems to be the best option to get accurate results. IT companies offer digital solutions that increase sales, define goals, manage stock, enhance skills, and more with minimal effort. They make sure to enhance every stage of business starting from the management to sales to make it more efficient and effortless which saves a lot of time and is valuable for all businesses. 

As there are tons of IT companies available offering top-notch services to the businesses out there, it becomes a task to sort the top IT companies which have the knowledge and experience to handle any situation.

To make your work easy TopSoftwareCompanies.co made a list of the top 10 IT companies in USA browsing the companies located in different cities such as Florida, Chicago, New York, Los Angeles, San Francisco, and more.

The companies are shortlisted based on many parameters like client reviews, work experience, development skills, average hourly rate, project size, company strength and many more.

The List of Top 10 Popular IT Companies in USA 2023

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